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2012 BRN Symposium

Agenda

Wednesday, February 22, 2012
   
7:30 a.m. – 8:30 a.m. Registration
   
8:30 a.m. – 8:40 a.m. Welcome
  Helen M. Moore, Ph.D.
Office of Biorepositories and Biospecimen Research
National Cancer Institute, NIH
   
8:40 a.m. – 9:00 a.m. The Patient's Perspective on Biospecimen Science
  Peggy Devine. Founder and President
Cancer Information and Support Network
   
9: 00 a.m. – 10:00 a.m. Keynote Address, Title TBA
  Gene N. Herbek, M.D., FCAP
College of American Pathologists President Elect
  Question-and-Answer Session
   
10:00 a.m. – 10:20 a.m. Break
   
  Session: Examining the Effects of Preanalytical Factors on Protein Expression in Tissues
   
10:20 a.m. – 10:50 a.m. Effects of Intra-Operative Ischemia on Cancer and Normal Tissues
  Hartmut Juhl, M.D.
Indivumed
  Question-and-Answer Session
   
10:50 a.m. – 11:20 a.m. Intrinsic and Extrinsic Controls for FFPE Tissue
  David Rimm, M.D., PhD
Yale University
  Question-and-Answer Session
   
11:20 a.m. - 11:35 a.m. Developing a Research Program to Study the FFPE Manufacturing Process
  Helen Moore, Ph.D.
National Cancer Institute, NIH
  Question-and-Answer Session
   
11:35 a.m. – 11:50 a.m. The Biospecimen Research Database:  1100 Articles and Growing
  B. Paige Bass, Ph.D.
Kelly Government Solutions
National Cancer Institute, NIH
  Questions-and-Answer Session
   
11:50 a.m. – 1:30 p.m. Meet-the-Experts Working Lunch
   
  Session: RNA Stability in Biospecimens
   
1:30 p.m. – 2:00 p.m. Effects of Pre-Analytic Variables on Circulating MicroRNAs
  Hua Zhao, Ph.D.
Roswell Park Cancer Institute
  Question-and-Answer Session
   
2:00 p.m. – 2:30 p.m. Effects of Biospecimen Integrity, Intratumoral Heterogeneity, and Analytical Variance on Micoarray-Based Pharmacogenomics Tests of Breast Cancer
  Fraser Symmons, M.D.
MD Anderson

Christos Hatzis, Ph.D.
Nuvera Biosciences
  Question-and-Answer Session
   
2:30 p.m. – 3:00 p.m. Measurement of RNA Integrity in Biospecimens With Sentinel Pol-II RNAs
  Curt Hagedorn, M.D.
University of Utah
  Question-and-Answer Session
   
3:00 p.m. – 3:15 p.m. Comparison of Tissue Preservation Methods and Resulting RNA Quality in Gastrointestinal Tumors and Associated Benign Tissues
  Cheryl M. Lewis, Ph.D.
University of Texas Southwestern Medical Center
   
3:15 p.m. – 3:30 p.m.  A Formalin Fixation Procedure that Preserves Histology and Nucleic Acid Integrity
  Gianni Bussolati
University of Turin, Italy
   
  Question-and-Answer Session
   
3:30 p.m. – 3:50 p.m. Break
   
  Session: Biospecimen Science Around the World
   
3:50 p.m. – 4:20 p.m. SPIDIA Program Update
  Uwe Oelmueller, Ph.D.
QIAGEN
  Question-and-Answer Session
   
4:20 p.m. – 4:50 p.m. ISBER Biospecimen Working Group Update: From in silico Biospecimen Research to External Quality Assessment
  Fay Betsou, Ph.D.
Integrated Biobank of Luxembourg
  Question-and-Answer Session
   
4:50 p.m. – 5:20 p.m. Building a Biospecimen Base for the NCI Latin America Cancer Research Network
Silvina French, Ph.D.
SAIC-Frederick Inc.
National Cancer Institute at Frederick

Teri Brown
National Cancer Institute, NIH
  Jorge Gomez, M.D., Ph.D.,
Director, Office of Latin American Cancer Program Development
National Cancer Institute, NIH
  Question-and-Answer Session
   
5:20 p.m. – 5:30 p.m. Day 1 Closing Remarks
  Helen M. Moore, Ph.D.
National Cancer Institute, NIH
   
5:30 p.m. – 7:00 p.m. Poster Session
   

Thursday, February 23, 2012
   
7:30 a.m. – 8:00 a.m. Registration
   
8:00 a.m. – 9:00 a.m. Meet-the-Experts Morning Working Session
   
  Session: Selected Abstract Presentations
   
9:00 a.m. – 9:15 a.m. A Physical Sciences Approach to Biospecimen Research via High Content Screening
  Nicole Moore, Ph.D.
Office of Physical Sciences – Oncology
National Cancer Institute, NIH
   
9:15 a.m. – 9:30 a.m. Next-Generation Biospecimen Preservation at Ambient Temperature Based on the Use of Micron-Scale Scaffolds
  Michael Hogan, Ph.D.
IntegenX Corporation
   
9:30 a.m. – 9:45 a.m. Detection and Minimization of Microheterogeneity Damage to Macromolecules During Freezing and Drying of Biospecimens
  Alptekin Aksan, Ph.D.
University of Minnesota
   
9:45 a.m. – 10:00 a.m. Exposing the Criminal Record of Every Blood Sample:  Use of Somamer Technology and Sample Mapping Vectors to Mitigate False Biomarker Discoveries
  Rachel Ostroff, Ph.D.
SomaLogic, Inc.
   
10:00 a.m. – 10:15 a.m. Preservation, Extraction, and Analysis of Biomolecules in Complex Human Biofluids
  Niels H. H. Heegaard, M.D., Ph.D.
Statens Serum Institut
   
10:15 a.m. – 10:30 a.m. DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues
  Justin M. Craig
Dana-Farber Cancer Institute
   
  Question-and-Answer Sessions
   
10:30 a.m. – 10:50 a.m. Break
   
  Session: Measuring Protein Stability in Blood
   
10:50 a.m. – 11:20 a.m. Credentialing Plasma and Serum Biospecimen Banks for Proteomics Analyses
  Katherine Williams, Ph.D.
University of California, San Francisco
  Question-and-Answer Session
   
11:20 a.m. – 11:50 a.m. Investigations into the Effects of Blood Specimen Handling Procedures on Protein Integrity
  Daniel Chelsky,  Ph.D.
Caprion Proteomics
  Question-and-Answer Session
   
11:50 a.m. – 1:30 p.m. *Lunch & Poster Session
   
  Session: The Genotype-Tissue Expression Program--Acquisition of Normal Tissue to Study Genomic Variation
   
1:30 p.m. – 2:00 p.m. GTEx Program Overview
  Jeffery Struewing, M.D., M.S.
Simona Volpi, Ph.D., Pharm.D.
National Human Genome Research Institute, NIH
  Question-and-Answer Session
   
2:00 p.m. – 2:30 p.m. Acquisition of Normal Tissues for Research
  Carolyn Compton, M.D., Ph.D.
President, Critical Path Institute
  Question-and-Answer Session
   
2:30 p.m. – 3:00 p.m. Evaluating the Molecular Quality of Normal Tissues
  Kristen Ardlie, Ph.D.
Broad Institute of MIT and Harvard
  Question-and-Answer Session
   
3:00 p.m. – 3:20 p.m. Break
   
  Session: Ensuring Quality in Biospecimens
   
3:20 p.m. – 3:50 p.m. FDA perspective on Biospecimen Science
 

Alberto Gutierrez, Ph.D.
US Food and Drug Administration
  Question-and-Answer Session
   
3:50 p.m. – 4:20 p.m. College of American Pathologists' Biorepository Accreditation Program
  Denise Driscoll, M.S.
  Director, Laboratory Accreditation and Regulatory Affairs
College of American Pathologists
  Question-and-Answer Session
   
4:20 p.m. – 4:50 p.m. Mining the Biomedical Literature for Detailed Information About Biospecimens
  Paul Fearn, M.B.A.
University of Washington
  Question-and-Answer Session
   
4:50 p.m. Closing Remarks
  Helen Moore, Ph.D.
National Cancer Institute, NIH

*The cost of lunch is included as a part of the registration fee, for non-Federal employees. Federal Employees must purchase their lunch at the time they submit their registration.